The checkpoint inhibitor CD96 was shown conclusively to be an inhibitory receptor on human NK cells in the presence of multiple myeloma (MM) cells expressing CD155 CD96 knock out (KO) using CRISPR/Cas9 gene editing enhanced both NK cell cytotoxicity and cytokine release Efficient engineering of NK cells to genetically eliminate inhibitory receptor expression has the potential […]
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Entries by nacnkcell
The Irish Times – View full story
Collaboration between ONK Therapeutics and Dr. David Finlay’s group at Trinity College Dublin, Ireland Two-year Enterprise Ireland Innovation Partnership Programme (IPP) project grant of €373,295 Research to explore metabolic reprogramming and engineering of natural killer (NK) cells for improved cancer therapy Galway, Ireland and San Diego, USA, 8 June 2021 – ONK Therapeutics Ltd, an […]
Cytokine Inducible SH2 containing protein (CIS; encoded by the gene CISH) is a potent checkpoint in NK cell-mediated tumor immunity CISH knockout (KO) NK cells have been shown to be more efficient in eliminating cancer cells in in-vivo models Exclusive global license to WEHI patent for CISH KO in the field of NK cells builds […]
Agreement with the National University of Ireland, Galway (NUI Galway), supervised by leading expert in the cellular environment in Acute Myeloid Leukaemia (AML), Dr. Eva Szegezdi Funded by ONK Therapeutics, the research will support engineering and optimization of its dual-targeted NK cell therapy candidate for AML (ONKT104) Aims to explore the potential added benefit of certain gene […]
Professor Philippe Moreau brings 20 years of experience in clinical hematology Translational research head at University Hospital of Nantes, France World-renowned expert in multiple myeloma, leading clinical trials Joins US-based SAB members, Prof Malcolm Brenner MD, Ph.D. and Prof Jeffrey Miller MD Galway, Ireland, and San Diego, USA, 8 April 2021 – ONK Therapeutics Ltd, […]
License with NIH for intellectual property for a clinically-validated, GMP grade feeder cell line to enable robust natural killer (NK) cell expansion Enhances ONK Therapeutics’ evolving research efforts to scale up and support clinical trials Galway, Ireland, and San Diego, USA, 18 March 2021 – ONK Therapeutics Ltd, an innovative cell therapy company focused on […]
Nature BioPharma Dealmaker – View full story
Anthony Nolan Cell & Gene Therapy Services will provide umbilical cord blood and cord-derived NK cells to facilitate the development of ONK Therapeutics’ next-generation dual-targeted NK cell therapies Collaboration supports a common mission to improve the lives of patients with hematological malignancies and solid tumors London, UK and Galway, Ireland, and San Diego, USA 22 […]
Mary Reilly joins as COO, to lead the company’s international operations and drive growth ambitions to transition from a pre-clinical to a clinical-stage company 30 years’ experience in all aspects of global drug development and company operations Prior experience as COO at Opsona Therapeuticsas well as at BioInvent International, Neuramedy, Elan Pharmaceuticals, and Taro Pharmaceuticals […]